- Mr. McCloskey's marvelous mallards, the making of make way for ducklings, Emma Bland Smith ; illustrated by Becca Stadtlander
- Drop, an adventure through the water cycle, Emily Kate Moon
- How Emily saved the bridge, the story of Emily Warren Roebling and the building of the Brooklyn Bridge, Frieda Wishinsky ; pictures by Natalie Nelson
- Sitting on top of the world, Steven L. Richards
- Concrete, from the ground up, Larissa Theule ; illustrated by Steve Light
- Mars!, Earthlings welcome, by Mars ; (with Stacy McAnulty) ; illustrated by Mars (and Stevie Lewis)
- Four hundred souls, a community history of African America 1619-2019, edited by Ibram X. Kendi
- How science saved the Eiffel tower, by Emma Bland Smith ; illustrated by Lia Visirin
- The last winter, the scientists, adventurers, journeymen, and mavericks trying to save the world, Porter Fox
- The elements, written by Adrian Dingle
- The price of the ticket, collected nonfiction, 1948-1985, James Baldwin
- Cat, written by Juliet Clutton-Brock
- When the sky glows, Nell Cross Beckerman ; illustrated by David Litchfield
- Ducks overboard!, a true story of plastic in our oceans, Markus Motum
- She persisted in science, brilliant women who made a difference, written by Chelsea Clinton ; illustrated by Alexandra Boiger
- Francesco Tirelli's ice cream shop, Tamar Meir ; illustrated by Yael Albert ; translated by Noga Applebaum
- Spiders, worldwide webs, Tait Howard
- She caught the light, Williamina Stevens Fleming : astronomer, written by Kathryn Lasky ; illustrated by Julianna Swaney
- We are still here!, Native American truths everyone should know, Traci Sorell ; illustrated by Frané Lessac
- The science of baking, by Andrea Beaty and Dr. Theanne Griffith ; illustrations by Steph Stilwell
- Hope is an arrow, the story of Lebanese American poet Kahlil Gibran, Cory McCarthy ; illustrated by Ekua Holmes
- A crochet world of creepy creatures and cryptids, 40 amigurumi patterns for adorable monsters, mythical beings and more, Rikki Gustafson
- The best American science and nature writing 2021, Ed Yong, editor
- Midnight's borders, a people's history of modern India, Suchitra Vijayan
- Yayoi Kusama covered everything in dots and wasn't sorry, by Fausto Gilberti
- Go for the moon, a rocket, a boy, and the first moon landing, Chris Gall
- Groundhog day, by Gail Gibbons
- Cosmic queries, StarTalk's guide to who we are, how we got here, and where we're going, Neil deGrasse Tyson with James Trefil ; read by Neil deGrasse Tyson and Lauren Fortgang
- Jack Knight's brave flight, how one gutsy pilot saved the U.S. Air Mail Service, by Jill Esbaum ; illustrated by Stacy Innerst
- The key from Spain, Flory Jagoda and her music, by Debbie Levy ; illustrated by Sonja Wimmer
- John James Audubon painted birds, by Kate Coombs ; art by Seth Lucas
- Ivy the very determined dog, a true story, by Chris and Maureen Harrington ; illustrated by Charlotte Bruijn
- My first day at school, by Thomas Kingsley Troupe ; illustrated by Kat Uno
- Jane against the world, Roe v. Wade and the fight for reproductive rights, Karen Blumenthal
- A ghost in the throat, Doireann Ní Ghríofa
- Alan Turing, written by Ma Isabel Sánchez Vegara ; illustrated by Ashling Lindsay
- Alphamaniacs, builders of 26 wonders of the word, [by] Paul Fleischman ; art by Melissa Sweet
- Birds of prey, terrifying talons, Joe Flood
- Maker comics, written by Colleen AF Venable ; art by Kathryn Hudson
- The whale who swam through time, a 200-hundred-year journey in the Arctic, written by Alex Boersma and Nick Pyenson ; illustrated by Alex Boersma
- Now what?, a math tale, Robie H. Harris ; illustrated by Chris Chatterton
- When I grow up, the lost autobiographies of six Yiddish teenagers, Ken Krimstein
- Ocean!, waves for all, by Ocean (with Stacy McAnulty) ; illustrated by Ocean (and David Litchfield)
- Penguins & polar bears, a pretty cool introduction to the Arctic and Antarctic, written by Alicia Klepeis ; illustrated by Grace Helmer ; edited by Maria-Elizabeth Niebius and Robert Klanten
- Bare tree and Little wind, a story for Holy Week, written by Mitali Perkins ; illustrated by Khoa Le
- Come to this court & cry, how the Holocaust ends, Linda Kinstler
- Moon!, Earth's best friend, by Moon (with Stacy McAnulty) ; illustrated by Moon (and Stevie Lewis)
- Georgia O'Keeffe, she saw the world in a flower, written by Gabrielle Balkan ; illustrated by Josy Bloggs
- Emily writes, Emily Dickinson and her poetic beginnings, Jane Yolen ; illustrated by Christine Davenier
- The view from the cheap seats, selected nonfiction, Neil Gaiman